Comparative genomic analysis of oral versus laryngeal and pharyngeal cancer

Comparative genomic analysis of oral versus laryngeal and pharyngeal cancer

Objective: Locally advanced oral squamous cell carcinoma (OSCC) shows lower locoregional control and disease specific survival rates than laryngeal and pharyngeal squamous cell carcinoma (L/P-SCC) after definitive chemoradiotherapy treatment. Despite clinical factors, this can point towards a differ...

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Bibliographic Details
Main Authors: van den Brekel, M.W.M (Author), Vens, C. (Author), Verhagen, C.V.M (Author), Verheij, M. (Author), Vossen, D.M (Author), Wessels, L.F.A (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adult
aged
Aged
allelic imbalance
Article
bioinformatics
Carcinoma, Squamous Cell
casp8 protein
CASP8 protein, human
caspase 8
Caspase 8
Chemoradiotherapy
clinical outcome
comparative genomic hybridization
Comparative Genomic Hybridization
comparative study
copy number variation
DNA sequence
DNA sequence analysis
female
Female
gene frequency
General surgery
Genes, ras
genetic analysis
genetics
genomics
Genomics
Head and neck squamous cell carcinoma
homologous recombination
Homologous recombination
hras protein
human
human tissue
Humans
laminin alpha2
Laryngeal neoplasms
Laryngeal Neoplasms
larynx squamous cell carcinoma
larynx tumor
major clinical study
male
Male
middle aged
Middle Aged
Mouth Neoplasms
mouth squamous cell carcinoma
mouth tumor
Mutation
nonhuman
nsd1 protein
oncogene ras
Oral cancer
oropharynx squamous cell carcinoma
Pharyngeal neoplasms
Pharyngeal Neoplasms
pharynx cancer
point mutation
Point Mutation
priority journal
protein
recombination repair
Retrospective Studies
retrospective study
somatic mutation
squamous cell carcinoma
unclassified drug
Wart virus
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