Nivolumab vs investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression

Objectives: We report 2-year results from CheckMate 141 to establish the long-term efficacy and safety profile of nivolumab and outcomes by tumor PD-L1 expression in patients with recurrent or metastatic (R/M),platinum-refractory squamous cell carcinoma of the head and neck (SCCHN). Methods: Patient...

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Bibliographic Details
Main Authors:	Blumenschein, G., Jr (Author), Colevas, A.D (Author), Docampo, L.C.I (Author), Even, C. (Author), Fayette, J. (Author), Ferris, R.L (Author), Gillison, M.L (Author), Guigay, J. (Author), Haddad, R. (Author), Harrington, K.J (Author), Jayaprakash, V. (Author), Kasper, S. (Author), Kiyota, N. (Author), Li, L. (Author), Licitra, L. (Author), Lynch, M. (Author), Rordorf, T. (Author), Saba, N.F (Author), Tahara, M. (Author), Vokes, E.E (Author), Worden, F. (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	anemia Antineoplastic Agents, Immunological Article aspartate aminotransferase aspartate aminotransferase blood level asthenia B7-H1 Antigen body weight loss cancer growth cancer patient cancer recurrence cancer survival cancer survivor Carcinoma, squamous cell of head and neck CD274 protein, human CD274 protein, human (PD-L1 Protein, Human) cetuximab clinical outcome Clinical Trial, Phase III comparative study controlled study diabetes mellitus docetaxel drug efficacy drug safety drug therapy drug withdrawal endocrine disease fatigue follow up gastrointestinal disease general condition deterioration Head and Neck Neoplasms head and neck squamous cell carcinoma heart failure human Humans hyperamylasemia hypercalcemia hypersensitivity hyponatremia hypothyroidism immunological antineoplastic agent Immunotherapy kidney disease liver disease long term survival lung infection major clinical study metabolism metastasis methotrexate nausea Neoplasm Metastasis Neoplasm Recurrence, Local nephritis nivolumab Nivolumab open study overall survival Papillomaviridae (HPV, Human Papillomavirus Viruses) pathology phase 3 clinical trial (topic) platinum pneumonia priority journal Programmed Cell Death 1 Receptor programmed death 1 ligand 1 progression free survival protein expression randomized controlled trial recurrent disease refractory head and neck squamous cell carcinoma skin disease Squamous Cell Carcinoma of Head and Neck survival analysis Survival Analysis Survivors (Long-term Survivors) treatment duration triacylglycerol lipase triacylglycerol lipase blood level tumor recurrence Wart virus
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Nivolumab vs investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression

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