Frequent HPV-independent p16/INK4A overexpression in head and neck cancer

Objectives: p16INK4A (p16) is the most widely used clinical biomarker for Human Papillomavirus (HPV) in head and neck squamous cell cancer (HNSCC). HPV is a favourable prognostic marker in HNSCC and is used for patient stratification. While p16 is a relatively accurate marker for HPV within the orop...

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Bibliographic Details
Main Authors:	Chakravarthy, A.R (Author), Chester, K. (Author), Feber, A. (Author), Fenton, T.R (Author), Forde, C.T (Author), Forster, M. (Author), Hayes, D.N (Author), Jay, A. (Author), Jones, T.M (Author), Kalavrezos, N. (Author), Lechner, M. (Author), Masterson, L. (Author), McIndoe, R.A (Author), O'Flynn, P. (Author), Vaz, F.M (Author), Walter, V. (Author), Weinberger, P.M (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	Alphapapillomavirus Article biological marker Biomarkers, Tumor cell cycle G1 phase cell cycle S phase cohort analysis Cohort Studies copy number variation cyclin dependent kinase inhibitor 2A Cyclin-Dependent Kinase Inhibitor p16 G1 Phase gene amplification gene inactivation gene mutation genetics head and neck cancer Head and Neck Neoplasms head and neck tumor histone H3 human Humans isolation and purification metabolism methyltransferase mutation Mutation oropharynx carcinoma papillomavirus infection Papillomavirus Infections pathology priority journal protein expression protein p16 RNA sequence S Phase Squamous Cell Carcinoma of Head and Neck tumor marker upregulation Up-Regulation virology virus transcription Wart virus
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Frequent HPV-independent p16/INK4A overexpression in head and neck cancer

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