DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

Objectives: Head and neck squamous cell carcinoma (HNSCC) is often associated with chronic systemic inflammation (SI). In the present study, we assessed if DNA methylation-derived SI (mdSI) indices: Neutrophil-to-Lymphocyte ratio (mdNLR) and Lymphocyte-to-Monocyte ratio (mdLMR) are associated with t...

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Bibliographic Details
Main Authors: Ambatipudi, S. (Author), Davey Smith, G. (Author), Gaunt, T.R (Author), Ho, K.M (Author), Kazmi, N. (Author), Kelsey, K.T (Author), Koestler, D.C (Author), Langdon, R. (Author), McArdle, W. (Author), Ness, A.R (Author), Pawlita, M. (Author), Penfold, C. (Author), Pring, M. (Author), Relton, C.L (Author), Richmond, R.C (Author), Ring, S.M (Author), Suderman, M. (Author), Thomas, S. (Author), Waterboer, T. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
Alcohol Drinking
Antibodies, Viral
Article
Biomarkers, Tumor
blood
C reactive protein
cancer mortality
cancer prognosis
cancer survival
carcinogenesis
case control study
Case-Control Studies
comorbidity
Comorbidity
controlled study
CpG island
CpG Islands
C-Reactive Protein
Datasets as Topic
DNA methylation
DNA Methylation
drinking behavior
E6 protein, Human papillomavirus type 16
epidemiology
female
Female
genetic association
genetics
Head and neck cancer
Head and Neck Neoplasms
head and neck squamous cell carcinoma
head and neck tumor
human
Human papillomavirus 16
Human papillomavirus type 16
Humans
immunology
inflammation
Inflammation
information processing
isolation and purification
Kaplan Meier method
Kaplan-Meier Estimate
leukocyte count
Leukocyte Count
lymphocyte monocyte ratio
Lymphocyte-to-monocyte ratio
major clinical study
male
Male
mdNLR
middle aged
Middle Aged
mortality
mortality risk
neutrophil lymphocyte ratio
Neutrophil-to-lymphocyte ratio
odds ratio
Odds Ratio
Oncogene Proteins, Viral
oncoprotein
overall survival
Overall survival
papillomavirus infection
Papillomavirus Infections
priority journal
proportional hazards model
Proportional Hazards Models
protein E6
repressor protein
Repressor Proteins
smoking
Smoking
Squamous Cell Carcinoma of Head and Neck
survival analysis
survival rate
systemic inflammation
Systemic inflammation
tumor marker
very elderly
virology
virus antibody
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