Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner

Objectives: No prognostic or predictive biomarkers for oral squamous cell carcinoma (OSCC) exist. We aimed to discover novel proteins, altered in OSCC, to be further investigated as potential biomarkers, and to improve understanding about pathways involved in OSCC. Materials and Methods: Proteomic s...

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Bibliographic Details
Main Authors:	Dickinson, A. (Author), Haglund, C. (Author), Hagström, J. (Author), Joenväärä, S. (Author), Mäkitie, A. (Author), Saraswat, M. (Author), Silén, R. (Author), Silén, S. (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	adenylate kinase adult Adult aged Aged Aged, 80 and over alpha crystallin ANP32B Article Biomarkers, Tumor CA1 calcium signaling calreticulin cancer classification cancer localization cancer staging carbonate dehydratase I cell migration cofilin 1 cohort analysis complement component C4b binding protein controlled study desmin down regulation female Female gelatinase B Head and neck cancer heat shock protein 90 human human tissue Humans immunocompetent cell immunoglobulin enhancer binding protein immunohistochemistry Immunohistochemistry keratin keratin type I lumican macrophage migration inhibition factor male Male mass spectrometry Mass Spectrometry metabolism middle aged Middle Aged mouth squamous cell carcinoma myoglobin myosin Neoplasm Staging Neutrophil defensin 1 nucleosome assembly protein 1 OPLS-DA Oral squamous cell carcinoma pathogenesis pathology peripherin periplakin polyadenylic acid binding protein principal component analysis priority journal procedures prohibitin prosaposin protein expression proteomics Proteomics RNA polymerase II S100A7 serine peptidase inhibitor Kazal type 5 Squamous Cell Carcinoma of Head and Neck stathmin tenascin thymosin beta10 Tissue Array Analysis tissue microarray Tissue proteomics tongue Tongue Tongue cancer Tongue Neoplasms tongue tumor tropomyosin tumor marker ubiquinol cytochrome c reductase upregulation very elderly
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Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner

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