Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma

Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma

Introduction: In head and neck squamous cell carcinoma (HNSCC) high numbers of tumor infiltrating CD8 T cells in the tumor microenvironment are associated with better outcome. However, no investigators have employed automated image analysis on whole slide images to permit CD8 scores for use in clini...

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Bibliographic Details
Main Authors: Ahmad, F. (Author), Ferris, R.E (Author), Hartman, D.J (Author), Pantanowitz, L. (Author), Rimm, D. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
algorithm
Algorithms
Article
cancer survival
CD8
CD8 antigen
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
cell density
cell infiltration
female
Female
fluorescence
follow up
Follow-Up Studies
Head and neck
Head and Neck Neoplasms
head and neck squamous cell carcinoma
head and neck tumor
HPV
human
human tissue
Humans
image analysis
Image analysis
image processing
Image Processing, Computer-Assisted
immunocompetent cell
immunohistochemistry
Immunohistochemistry
immunology
Immunology
Immunotherapy
lymphocyte count
Lymphocyte Count
major clinical study
male
Male
mortality
oropharynx squamous cell carcinoma
overall survival
papillomavirus infection
pathology
priority journal
procedures
Quantification
quantitative analysis
Score
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
survival analysis
Survival Analysis
survival rate
tissue section
tumor microenvironment
Tumor Microenvironment
Whole slide image
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