The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines

The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines

Objectives: We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer cell lines that have remained uncharacterized despite being used as model systems for decades. Materials and Methods: We performed exome sequencing on 14 oral cavity UM-SCC cell lines and denote the mutational p...

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Bibliographic Details
Main Authors: Birkeland, A.C (Author), Brenner, J.C (Author), Carey, T.E (Author), Devenport, S.N (Author), Foltin, S.K (Author), Hoesli, R.C (Author), Jewell, B.M (Author), Jiang, H. (Author), Kulkarni, A. (Author), Ludwig, M.L (Author), Mann, J.E (Author), Michmerhuizen, N.L (Author), Shuman, A.G (Author), Spector, M.E (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
Article
CASP8 protein, human
caspase 8
Caspase 8
CDKN2A protein, human
Cell Line, Tumor
Cell Lines
Class I Phosphatidylinositol 3-Kinases
controlled study
copy number variation
cyclin dependent kinase inhibitor 2A
Cyclin-Dependent Kinase Inhibitor p16
DNA Copy Number Variations
Exome
fluorescence in situ hybridization
gene amplification
gene deletion
gene mutation
genetics
genomics
HNSCC
human
human cell
Humans
immunoblotting
karyotyping
Karyotyping
Mouth Neoplasms
mouth squamous cell carcinoma
mouth tumor
mutation
Mutation
Oral cancer
pathology
phosphatidylinositol 4,5 bisphosphate 3 kinase
PIK3CA protein, human
priority journal
protein expression
protein p53
RNA sequence
single nucleotide polymorphism
squamous cell carcinoma cell line
Squamous Cell Carcinoma of Head and Neck
TP53 protein, human
tumor cell line
Tumor Suppressor Protein p53
UM-SCC
whole exome sequencing
Whole Exome Sequencing
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