Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma

Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma

Objectives: Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to tumor recurrence/metastasis and abysmal ~35% 5-year survival. Causal links have been established between Epithelial Growth Fac...

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Bibliographic Details
Main Authors: Amelio, A.L (Author), Castilho, R.M (Author), do Nascimento-Filho, C.H.V (Author), Liu, P. (Author), Musicant, A.M (Author), Parag-Sharma, K. (Author), Tasoulas, J. (Author), Twomey, C. (Author), Zhu, Z. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2021
Subjects:
amino acid sequence
apoptosis
Article
cancer stem cell
carcinogenicity
Carcinoma, Mucoepidermoid
caspase 3
caspase 7
cell cycle arrest
cell cycle G1 phase
Cell Line, Tumor
cell proliferation
cell survival
cell viability
cisplatin
colony formation
controlled study
cudc 101
CUDC-101
data analysis software
drug cytotoxicity
Drug synergy
drug tolerance
Drug tolerance
EGFR
EGFR protein, human
emetine
enzyme activation
epidermal growth factor receptor
epidermal growth factor receptor kinase inhibitor
ErbB Receptors
erlotinib
exon
genetics
HDAC
Head and neck cancer
histone acetylation
histone deacetylase inhibitor
Histone Deacetylase Inhibitors
human
human cell
Humans
IC50
Lynx
metabolism
monotherapy
Mucoepidermoid carcinoma
mucoepidermoid tumor
pathology
phenotype
priority journal
Salivary cancer
Salivary Gland Neoplasms
salivary gland tumor
signal transduction
synergistic effect
tumor cell line
tumor spheroid
unclassified drug
upregulation
vorinostat
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