Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young

Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young

Metabolic syndrome (MetS) is a known risk factor for cognitive decline. Using polygenic rat models selectively bred for high and low intrinsic exercise capacity and simultaneously modelling as low and high innate risk factor for MetS respectively, we have previously shown that adult animals with low...

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Bibliographic Details
Main Authors: Britton, S.L (Author), Kainulainen, H. (Author), Koch, L.G (Author), Lensu, S. (Author), Mäkinen, E. (Author), Nokia, M.S (Author), Wikgren, J. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2021
Subjects:
adult
animal
animal behavior
animal experiment
animal model
Animals
Article
cognition
Cognition
cognitive defect
comparative study
controlled study
exercise capacity
fitness
genetic association
genetic risk
habituation
health hazard
high capacity runner
locomotion
low capacity runner
maze test
mental deficiency
Metabolic Syndrome
metabolic syndrome X
nonhuman
open field
open field test
physical activity
Physical Conditioning, Animal
prepulse inhibition
pre-pulse inhibition
priority journal
rat
Rats
risk assessment
risk factor
Risk Factors
runner
spatial learning
startle
startle reflex
T-maze test
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