Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine

Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine

Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely reported. In this study, mice were administered with cocaine (20 mg/kg/day) or veh...

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Bibliographic Details
Main Authors: Ávila-Gámiz, F. (Author), Castilla-Ortega, E. (Author), Gil-Rodríguez, S. (Author), Ladrón de Guevara-Miranda, D. (Author), Mañas-Padilla, M.C (Author), Rodríguez de Fonseca, F. (Author), Santín, L.J (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2021
Subjects:
animal
animal behavior
Animals
anxiety
Anxiety
Behavior, Animal
cocaine
Cocaine
cocaine dependence
Cocaine-Related Disorders
cognitive defect
Cognitive Dysfunction
Elevated plus maze
Forced swimming
Maze Learning
maze test
Mice
mouse
Place recognition memory
Spatial working memory
swimming
Swimming
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