FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety

FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety

FTY720 (fingolimod) is an analog of sphingosine, a ubiquitous sphingolipid. Phosphorylated FTY720 (FTY720-P) non-selectively binds to sphingosine-1-phosphate receptors (S1PRs) and regulates multiple cellular processes including cell proliferation, inflammation, and vascular remodeling. We recently d...

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Bibliographic Details
Main Authors: Bhatnagar, S. (Author), Corbett, B. (Author), Luz, S. (Author), Moorthy, G.S (Author), Pearson-Leary, J. (Author), Sotuyo, N. (Author), Zuppa, A.F (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2021
Subjects:
adult
angiopoietin 1
animal
animal experiment
animal model
animal tissue
Animals
anxiety
Anxiety
Article
blood vessel density
controlled study
corticosterone
corticosterone blood level
corticotropin
corticotropin blood level
drug therapy
electrospray
endothelin 1
erythrocyte count
fingolimod
Fingolimod Hydrochloride
forced swim test
FTY720
gelatinase A
HPA axis
hypophysis adrenal system
Hypothalamo-Hypophyseal System
hypothalamus hypophysis adrenal system
hypothalamus hypophysis system
liquid chromatography-mass spectrometry
lymphocyte
male
medial prefrontal cortex
Medial prefrontal cortex
nonhuman
open field test
physiological stress
Pituitary-Adrenal System
plasminogen
platelet derived growth factor A
rat
Rats
regulatory mechanism
reticulocyte count
S1PR
single drug dose
social anxiety
social interaction
social interaction test
sphingosine 1 phosphate receptor
Sphingosine-1-phosphate
Sphingosine-1-Phosphate Receptors
steady state
Stress
transforming growth factor beta2
vascular remodeling
Vascular remodeling
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