Sensitive determination of gentamicin in plasma using ion-exchange solid-phase extraction followed by UHPLC-MS/MS analysis

Sensitive determination of gentamicin in plasma using ion-exchange solid-phase extraction followed by UHPLC-MS/MS analysis

Background: Therapeutic drug monitoring (TDM) of gentamicin sulfate (GEN) is usually recommended, particularly in critical patients. Only a few reports had described the determination of GEN in plasma or plasma using LC-MS/MS. Objective: This study aimed to develop and validate a sensitive ultra-hig...

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Bibliographic Details
Main Authors: Anibaletto dos Santos, A.L (Author), Cezimbra da Silva, A.C (Author), de Lima Feltraco Lizot, L. (Author), Hahn, R.Z (Author), Hahn, S.R (Author), Linden, R. (Author), Meireles, Y.F (Author), Nonnenmacher, J.L (Author), Pagnussat, L.R (Author), Schneider, A. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
accuracy
anion exchange
Article
caffeic acid
drug determination
drug interaction
drug monitoring
extraction
gentamicin
Gentamicin
high performance liquid chromatography
immunoassay
ion exchange
limit of detection
limit of quantitation
liquid chromatography
liquid chromatography-mass spectrometry
mass spectrometry
measurement accuracy
measurement precision
multiple reaction monitoring
multiple sclerosis
Neonates
polyacrylamide gel electrophoresis
proteomics
quality control
retention time
solid phase extraction
Solid-phase extraction
tandem mass spectrometry
Therapeutic drug monitoring
UHPLC-MS/MS
ultra performance liquid chromatography
validation process
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