Performance of the Roche/Snibe electrochemiluminescent anti-SARS-COV-2 spike assays compared to the Roche/Abbott IgG nucleocapsid and Abbott IgM spike assays

Performance of the Roche/Snibe electrochemiluminescent anti-SARS-COV-2 spike assays compared to the Roche/Abbott IgG nucleocapsid and Abbott IgM spike assays

Introduction: We evaluated the Roche Elecsys Anti-SARS-CoV-2 and Snibe SARS-CoV-2 S-RBD IgG spike chemiluminescent immunoassays and compared them to existing Roche/Abbott nucleocapsid and Abbott IgM spike assays. Methods: We enrolled 184 SARS-CoV-2 RT-PCR positive samples and 215 controls (172 pre-p...

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Bibliographic Details
Main Authors: Aw, T.C (Author), Heng, P.Y (Author), Hoo, S.P (Author), Lau, C.S (Author), Phua, S.K (Author), Wong, M.S (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
anti-SARS-CoV-2 agent
Article
clinical feature
controlled study
coronavirus disease 2019
coronavirus nucleocapsid protein
cross reaction
diagnostic test accuracy study
early diagnosis
electrochemiluminescence immunoassay
Evaluation
human
immunoglobulin M
instrument validation
major clinical study
nonhuman
Nucleocapsid antibody assay
pandemic
process optimization
real time reverse transcription polymerase chain reaction
reverse transcription polymerase chain reaction
SARS-COV-2
sensitivity analysis
sensitivity and specificity
Severe acute respiratory syndrome coronavirus 2
Spike antibody assay
virus nucleocapsid
virus spike protein
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