Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium

Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium

Background: We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the m...

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Bibliographic Details
Main Authors: Beecher, C. (Author), Boerwinkle, E. (Author), Bressler, J. (Author), Christian, M.A (Author), Coore Desai, C. (Author), Grove, M.L (Author), Hessabi, M. (Author), Lee, M. (Author), Loveland, K.A (Author), McLaughlin, W. (Author), Rahbar, M.H (Author), Reece, J.-A (Author), Samms-Vaughan, M. (Author), Shakespeare-Pellington, S. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
African Caribbean
arsenic
Article
autism
Autism spectrum disorder (ASD)
bean
cadmium
case control study
child
codominance
controlled study
dietary exposure
dominant gene
educational status
environmental exposure
female
fish
fresh water
gene frequency
genetic model
genotype
glutathione transferase P1
GSTP1
heavy metal blood level
Heavy metals
heterozygote
homozygote
human
Interaction
isoleucine
Jamaica
lead
limit of detection
major clinical study
male
manganese
manganese blood level
mercury
preschool child
priority journal
protein protein interaction
salt water
sardine
sea food
shellfish
social status
sweet potato
tomato
valine
Weighted quantile sum (WQS) regression
yam
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