Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis triggered by STAT3 inhibition may provide a novel opportunity to explore a new effective therapeutic strategy for gastri...

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Bibliographic Details
Main Authors: Chu, Y. (Author), Ding, W. (Author), Huang, Q. (Author), Li, H. (Author), Li, M. (Author), Lin, Z. (Author), Liu, P. (Author), Lou, L. (Author), Lu, J. (Author), Mo, J. (Author), Ouyang, S. (Author), Turkson, J. (Author), Wang, J. (Author), Wang, Y. (Author), Yue, P. (Author), Zhang, X. (Author), Zhang, Z. (Author), Zhong, L. (Author), Zhu, J. (Author), Zhu, K. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Chemotherapy resistance
Ferroptosis
Gastric cancer
STAT3 inhibitor
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