Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation

Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation

Mitochondrial dysfunction and oxidative stress-mediated inflammasome activation play critical roles in the pathogenesis of the non-alcoholic fatty liver disease (NAFLD). Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1), or growth differentiation factor-15 (GDF15), is associated...

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Bibliographic Details
Main Authors: Chen, C. (Author), Chen, J. (Author), Chen, S. (Author), Eling, T. (Author), Lin, X. (Author), Peng, H. (Author), Sang, T. (Author), Wang, X. (Author), Wang, Y. (Author), Zhao, Q. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
AIM2 inflammasome
dsDNA
Hepatic steatosis
Lipid metabolism
NAG-1/GDF15
ROS
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