PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms

PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms

After birth, the intestine undergoes major changes to shift from an immature proliferative state to a functional intestinal barrier. By combining inducible lineage tracing and transcriptomics in mouse models, we identify a prodifferentiation PDGFRαHigh intestinal stromal lineage originating from pos...

Full description

Bibliographic Details
Main Authors: Benabid, A. (Author), Di Carlo, S.E (Author), Jacob, J.-M (Author), Kornobis, E. (Author), Legendre, R. (Author), Lepelletier, A. (Author), Ndiaye, P.D (Author), Nigro, G. (Author), Peduto, L. (Author), Stzepourginski, I. (Author), Varet, H. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
epithelial differentiation
IESC
inflammation
intestinal barrier
intestinal epithelial stem cells
intestinal repair
Lymphotoxin beta receptor
perivascular
postnatal intestinal maturation
rsubepithelial fibroblasts
stromal niches
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items