Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells

Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells

Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in the presence of mouse PSCs (mPSCs), while MYCN, a pro-growth...

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Bibliographic Details
Main Authors: Chen, Q. (Author), Fan, N. (Author), Gu, J. (Author), Huang, K. (Author), Lai, C. (Author), Lai, L. (Author), Li, H. (Author), Ouyang, Z. (Author), Pan, G. (Author), Shan, Y. (Author), Suo, Y. (Author), Tang, J. (Author), Wang, J. (Author), Wang, M. (Author), Zhang, Q. (Author), Zhang, T. (Author), Zhang, Y. (Author), Zhang, Z. (Author), Zhou, T. (Author), Zhu, Y. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
animal model of organ defects
embryonic complementation
human pluripotent stem cells
interspecies chimerism
regenerative medicine
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