The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is important to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal development and in adulthood. Pericytes in the CNS, heart...

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Bibliographic Details
Main Authors: Alitalo, K. (Author), Andaloussi Mäe, M. (Author), Anisimov, A. (Author), Arnold, T.D (Author), Betsholtz, C. (Author), Björkegren, J. (Author), Blomgren, K. (Author), Ernfors, P. (Author), Genové, G. (Author), Hansson, E.M (Author), He, L. (Author), Hemanthakumar, K.A (Author), Hu, Y. (Author), Lendahl, U. (Author), Leptidis, S. (Author), Liu, J. (Author), Mäkinen, T. (Author), Mocci, G. (Author), Muhl, L. (Author), Osman, A. (Author), Peng, X.-R (Author), Pietilä, R. (Author), Räsänen, M. (Author), Stritt, S. (Author), Sun, Y. (Author), Vanlandewijck, M. (Author), Xie, Y. (Author), Zhang, L. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
Angiotensin converting enzyme 2 (ACE2)
COVID-19
Endothelial Cells
pericytes
SARS-CoV-2
single-cell RNA-sequencing
Vasculature
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