Structural basis of nanobodies neutralizing SARS-CoV-2 variants

Structural basis of nanobodies neutralizing SARS-CoV-2 variants

Because of the evolutionary variants of SARS-CoV-2, development of broad-spectrum neutralizing antibodies resilient to virus escape is urgently needed. We identified a group of high-affinity nanobodies from camels immunized with receptor-binding domain (RBD) of SARS-CoV-2 spike protein and resolved...

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Bibliographic Details
Main Authors: Chen, X. (Author), Cui, Q. (Author), Fan, C. (Author), Geng, Y. (Author), Gong, R. (Author), Lan, Z. (Author), Li, L. (Author), Li, X. (Author), Qiao, H. (Author), Shi, Z. (Author), Sun, Z. (Author), Wang, L. (Author), Xu, J. (Author), Zhang, H. (Author), Zhang, X. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
bi-paratopic nanobodies
crystal structure
nanobody
receptor-binding domain
SARS-CoV-2 virus
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