A “spindle and thread” mechanism unblocks p53 translation by modulating N-terminal disorder

A “spindle and thread” mechanism unblocks p53 translation by modulating N-terminal disorder

Disordered proteins pose a major challenge to structural biology. A prominent example is the tumor suppressor p53, whose low expression levels and poor conformational stability hamper the development of cancer therapeutics. All these characteristics make it a prime example of “life on the edge of so...

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Main Authors: Abelein, A. (Author), Arsenian-Henriksson, M. (Author), Chen, G. (Author), Fritz, N. (Author), Ghadessy, F.J (Author), Ilag, L.L (Author), Johansson, J. (Author), Kaldmäe, M. (Author), Koeck, P.J.B (Author), Kronqvist, N. (Author), Lama, D. (Author), Landreh, M. (Author), Lane, D.P (Author), Ng, A.S (Author), Nilsson, L. (Author), Österlund, N. (Author), Rising, A. (Author), Sabatier, P. (Author), Sahin, C. (Author), Saluri, M. (Author), Sarr, M. (Author), Sedimbi, S. (Author), Siau, J.W (Author), Väänänen, V.A (Author), Vojtesek, B. (Author), Vosselman, T. (Author), Zhong, X. (Author), Zubarev, R.A (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
intrinsically disordered proteins
protein folding
protein translation
tumor suppressor
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