Synthesis and exploration of a novel chlorobenzylated 2-aminothiazole-phenyltriazole hybrid as migratory inhibitor of B16F10 in melanoma cells
In the study presented here, a novel chlorobenzylated bi-heterocyclic hybrid molecule (7) was synthesized and its structural confirmation was carried out by IR, 1H-NMR, 13C-NMR and CHN analysis data. This compound 7 was subjected to biological study with B16F10 mouse melanoma cells. The anti-prolife...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Inc.
2019
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| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 03980nam a2200793Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1016-j.toxrep.2019.08.016 | ||
| 008 | 220121s2019 CNT 000 0 und d | ||
| 020 | |a 22147500 (ISSN) | ||
| 245 | 1 | 0 | |a Synthesis and exploration of a novel chlorobenzylated 2-aminothiazole-phenyltriazole hybrid as migratory inhibitor of B16F10 in melanoma cells |
| 260 | 0 | |b Elsevier Inc. |c 2019 | |
| 650 | 0 | 4 | |a 2 (2 amino 1,3 thiazol 4 yl)acetohydrazide |
| 650 | 0 | 4 | |a 2 [2 (2 amino 1,3 thiazol 4 yl)acetyl] n phenyl 1 hydrazinecarbothioamide |
| 650 | 0 | 4 | |a 2-Aminothiazole |
| 650 | 0 | 4 | |a 4 ({5 [(4 chlorophenyl)sulfanyl 4 phenyl 4h 1,2,4 triazol 3 yl}methyl) 1,3 thiazol 2 amine |
| 650 | 0 | 4 | |a 5 [(2 amino 1,3 thiazol 4 yl)methyl] 4 phenyl 4h 1,2,4 triazole 3 thiol |
| 650 | 0 | 4 | |a animal cell |
| 650 | 0 | 4 | |a antineoplastic activity |
| 650 | 0 | 4 | |a Anti-proliferation |
| 650 | 0 | 4 | |a antiproliferative activity |
| 650 | 0 | 4 | |a Article |
| 650 | 0 | 4 | |a B16-F10 cell line |
| 650 | 0 | 4 | |a biochemical analysis |
| 650 | 0 | 4 | |a biological activity |
| 650 | 0 | 4 | |a blood brain barrier |
| 650 | 0 | 4 | |a carbon nuclear magnetic resonance |
| 650 | 0 | 4 | |a cell assay |
| 650 | 0 | 4 | |a cell viability |
| 650 | 0 | 4 | |a chemical structure |
| 650 | 0 | 4 | |a controlled study |
| 650 | 0 | 4 | |a drug absorption |
| 650 | 0 | 4 | |a drug bioavailability |
| 650 | 0 | 4 | |a drug synthesis |
| 650 | 0 | 4 | |a elemental analysis |
| 650 | 0 | 4 | |a heterocyclic compound |
| 650 | 0 | 4 | |a infrared spectroscopy |
| 650 | 0 | 4 | |a intestine absorption |
| 650 | 0 | 4 | |a matrix metalloproteinase |
| 650 | 0 | 4 | |a Matrix metalloproteinase |
| 650 | 0 | 4 | |a melanoma |
| 650 | 0 | 4 | |a melanoma cell line |
| 650 | 0 | 4 | |a membrane permeability |
| 650 | 0 | 4 | |a migration inhibition |
| 650 | 0 | 4 | |a molecular docking |
| 650 | 0 | 4 | |a mouse |
| 650 | 0 | 4 | |a MTT assay |
| 650 | 0 | 4 | |a nonhuman |
| 650 | 0 | 4 | |a polyacrylamide gel electrophoresis |
| 650 | 0 | 4 | |a priority journal |
| 650 | 0 | 4 | |a proton nuclear magnetic resonance |
| 650 | 0 | 4 | |a Triazole |
| 650 | 0 | 4 | |a triazole derivative |
| 650 | 0 | 4 | |a unclassified drug |
| 650 | 0 | 4 | |a wound healing assay |
| 650 | 0 | 4 | |a zymography |
| 650 | 0 | 4 | |a Zymography |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1016/j.toxrep.2019.08.016 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071430720&doi=10.1016%2fj.toxrep.2019.08.016&partnerID=40&md5=a9f8fd44a69bd42570fccd8e82377572 | ||
| 520 | 3 | |a In the study presented here, a novel chlorobenzylated bi-heterocyclic hybrid molecule (7) was synthesized and its structural confirmation was carried out by IR, 1H-NMR, 13C-NMR and CHN analysis data. This compound 7 was subjected to biological study with B16F10 mouse melanoma cells. The anti-proliferative results showed that 7 showed no significant toxicity at concentrations ranging of 0–44 μM. The treatment of B16F10 cells with 7 at aforementioned concentration range indicated that migration of cells was significantly lower than that of the control cells in a dose dependent manner. The possible migration inhibitory effect of these melanoma cells was further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells. It was inferred from our results that 7 was not affecting the expression and activity of these enzymes. Some other zinc-dependent matrix metalloproteinases (MMPs) were involved in the inhibitory progression. Taken together, compound 7 inhibited migrations of B16F10 mouse melanoma cells. Therefore, it may deserve consideration as a potential agent for the treatment of cancer. © 2019 | |
| 700 | 1 | 0 | |a Athar Abbasi, M. |e author |
| 700 | 1 | 0 | |a Aziz-ur-Rehman |e author |
| 700 | 1 | 0 | |a Hassan, M. |e author |
| 700 | 1 | 0 | |a Kim, S.J. |e author |
| 700 | 1 | 0 | |a Raza, H. |e author |
| 700 | 1 | 0 | |a Rehman Sadiq Butt, A. |e author |
| 700 | 1 | 0 | |a Seo, S.-Y. |e author |
| 700 | 1 | 0 | |a Shah, S.A.A. |e author |
| 700 | 1 | 0 | |a Siddiqui, S.Z. |e author |
| 700 | 1 | 0 | |a Yu, S.-M. |e author |
| 773 | |t Toxicology Reports |x 22147500 (ISSN) |g 6, 897-903 | ||