Large-Volume Hyperthermia for Safe and Cost-Effective Targeted Drug Delivery Using a Clinical Ultrasound-Guided Focused Ultrasound Device

Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnetic resonance (MR)-guided focused ultrasound (FUS) systems can generate well-controlled volumetric hyperthermia using re...

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Bibliographic Details
Main Authors:	Carlisle, R. (Author), Coussios, C.C (Author), Cranston, D. (Author), Gleeson, F.V (Author), Gray, M. (Author), Lyon, P.C (Author), Mannaris, C. (Author), Wu, F. (Author)
Format:	Article
Language:	English
Published:	Elsevier Inc. 2021
Subjects:	adenocarcinoma Adenocarcinoma adverse event animal animal experiment animal tissue Animals Antibiotics, Antineoplastic antineoplastic antibiotic Article bovine Cattle Chemotherapy Chemotherapy agents Clinical translation Colorectal Neoplasms colorectal tumor Controlled drug delivery controlled study cost benefit analysis Cost effectiveness cost effectiveness analysis Cost-Benefit Analysis devices disease exacerbation Drug delivery drug delivery system Drug Delivery Systems Drug products drug release echography ex vivo study Focused ultrasound heat sensitivity heating Heating strategy High throughput High-intensity focused ultrasound histopathology human Humans hyperthermia Hyperthermia Hyperthermia, Induced interventional ultrasonography liposome Liposomes liver Liver Liver Neoplasms liver tumor lyso thermosensitive liposome Lyso-thermosensitive liposomal doxorubicin Magnetic resonance Mammals nonhuman pathology Preclinical studies priority journal procedures process optimization Real time systems rib Ribs safety Targeted drug delivery temperature Temperature Therapeutic ultrasound Thermal dose ThermoDox thermometry Thermometry Thermosensitive liposomes thermotherapy tumor volume Tumors Ultrasonic devices Ultrasonography Ultrasonography, Interventional ultrasound Ultrasound Ultrasound guided ultrasound guided high intensity focused ultrasound unclassified drug
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Large-Volume Hyperthermia for Safe and Cost-Effective Targeted Drug Delivery Using a Clinical Ultrasound-Guided Focused Ultrasound Device

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