Suppressors of amyloid-β toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism

Suppressors of amyloid-β toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism

High-level production of recombinant proteins in industrial microorganisms is often limited by the formation of misfolded proteins or protein aggregates, which consequently induce cellular stress responses. We hypothesized that in a yeast Alzheimer's disease (AD) model overexpression of amyloid...

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Bibliographic Details
Main Authors: Chen, X. (Author), Engqvist, M.K.M (Author), Ishchuk, O.P (Author), Ji, B. (Author), Li, X. (Author), Petranovic, D. (Author), Siewers, V. (Author), Vorontsov, E. (Author), Wang, Y. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2022
Subjects:
Alzheimers disease
Amino acids
Amyloid-β
Biochemistry
Biosynthesis
Cell engineering
Cell stress
Cellular stress
Cytology
Disease models
Glycoproteins
Metabolic engineering
Metabolism
Neurodegenerative diseases
Peptides
Protein aggregation
Protein misfolding
Protein misfolding and aggregation
Recombinant protein productions
Recombinant proteins
Transcription
Transcription factors
Yeast
Yeast cell
Yeast cell factories
Yeast cell factory
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