Suppressors of amyloid-β toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism
High-level production of recombinant proteins in industrial microorganisms is often limited by the formation of misfolded proteins or protein aggregates, which consequently induce cellular stress responses. We hypothesized that in a yeast Alzheimer's disease (AD) model overexpression of amyloid...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Academic Press Inc.
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |