Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages

Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages

Streptococcus mutans (S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin (IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogen...

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Bibliographic Details
Main Authors: Chung, J. (Author), Lee, H.A (Author), Na, H.S (Author), Park, E. (Author), Park, M.H (Author), Song, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2018
Subjects:
AIM2 protein, human
Blotting, Western
calcium binding protein
Calcium-Binding Proteins
CARD Signaling Adaptor Proteins
Caspase 1
caspase recruitment domain signaling protein
cryopyrin
DNA binding protein
DNA-Binding Proteins
enzyme linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay
human
Humans
Immunity, Innate
immunology
inflammasome
Inflammasomes
innate immunity
interleukin 1beta
interleukin 1beta converting enzyme
Interleukin-1beta
macrophage
Macrophages
NLR Family, Pyrin Domain-Containing 3 Protein
NLRC4 protein, human
NLRP3 protein, human
signal transduction
Signal Transduction
Streptococcus mutans
tumor necrosis factor
Tumor Necrosis Factor-alpha
Western blotting
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