Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

Genome-wide association studies (GWAS) in admixed populations such as African Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk scores (PRS). Based on the observations that many disease-causing genes are shared between AA and European ancestry (EA) populations...

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Main Authors: Abreu, M. (Author), Agrawal, A. (Author), Chan, G. (Author), Edenberg, H.J (Author), Foroud, T. (Author), Hesselbrock, V. (Author), Kamarajan, C. (Author), Lai, D. (Author), Liu, Y. (Author), Meyers, J.L (Author), Nurnberger, J.I., Jr (Author), Plawecki, M.H (Author), Porjesz, B. (Author), Schuckit, M. (Author), Schwantes-An, T.-H (Author), Wetherill, L. (Author), Zhang, P. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
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