BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

Age-related osteoporosis is characterized by the accumulation of senescent osteoblastic cells in bone microenvironment and significantly reduced osteogenic differentiation. Clearing of the senescent cells is helpful to improve bone formation in aged mice. Bone morphogenetic protein 9 (BMP9), a multi...

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Bibliographic Details
Main Authors: Chen, X.-J (Author), Kong, X.-K (Author), Liu, J.-M (Author), Sun, L.-H (Author), Tao, B. (Author), Xu, J.-Z (Author), Yang, Y.-Y (Author), Zhang, D. (Author), Zhang, L.-L (Author), Zhao, H.-Y (Author), Zhou, Y.-M (Author), Zhu, K.-C (Author)
Format: Article
Language:English
Published: Springer Nature 2022
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