Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

The entity of DNA N6-methyladenine (6mA) in mammals remains elusive and subsequently its roles in diseases are poorly understood. Here we exploited a bacterial DNA contamination-free and ultrasensitive UHPLC-MS/MS assay to reassess DNA 6mA in human glioblastomas and unveiled that DNA 6mA (~0.08 ppm)...

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Bibliographic Details
Main Authors: Chen, S. (Author), Dai, P. (Author), Gao, Z. (Author), Jiang, G. (Author), Lai, W. (Author), Li, Y. (Author), Liang, Z. (Author), Lyu, C. (Author), Ma, C. (Author), Ma, W. (Author), Niu, Y. (Author), Tong, W.-M (Author), Wang, H. (Author), Wang, Y. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
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