Myosin VI regulates the spatial organisation of mammalian transcription initiation

Myosin VI regulates the spatial organisation of mammalian transcription initiation

During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this is a hallmark of genome regulation in mammalian cells, the mechanisms concerning the assembly, organisation and stability remain unknown. He...

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Bibliographic Details
Main Authors: Aaron, J. (Author), Chew, T.-L (Author), Cook, A.W (Author), dos Santos, Á (Author), Fili, N. (Author), Gebhardt, J.C.M (Author), Gough, R.E (Author), Grosse-Berkenbusch, A. (Author), Hari-Gupta, Y. (Author), Martin-Fernandez, M. (Author), Percipalle, P. (Author), Reed, H.C.W (Author), Toseland, C.P (Author), Venit, T. (Author), Wait, E. (Author), Wang, L. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
cell component
cell nucleus
Cell Nucleus
chromosome
enzyme
enzyme activity
gene expression
genetic transcription
genetics
genome
genomics
mammal
Mammals
metabolism
myosin heavy chain
Myosin Heavy Chains
myosin VI
paternal care
protein
RNA
RNA polymerase II
RNA Polymerase II
Transcription, Genetic
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