Immunosuppressive niche engineering at the onset of human colorectal cancer

Immunosuppressive niche engineering at the onset of human colorectal cancer

The evolutionary dynamics of tumor initiation remain undetermined, and the interplay between neoplastic cells and the immune system is hypothesized to be critical in transformation. Colorectal cancer (CRC) presents a unique opportunity to study the transition to malignancy as pre-cancers (adenomas)...

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Main Authors: Anderson, A.R.A (Author), Baker, A.-M (Author), Cross, W.C.H (Author), Gatenbee, C.D (Author), Graham, T.A (Author), Hasan, S.Y (Author), Jansen, M. (Author), Lakatos, E. (Author), Leedham, S. (Author), Martinez, P. (Author), Neves, M.P (Author), Robertson-Tessi, M. (Author), Rodriguez-Justo, M. (Author), Schenck, R.O (Author), Sottoriva, A. (Author), Strobl, M. (Author), West, J. (Author), Whelan, C.J (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
adenoma
Adenoma
antigen
Biological Evolution
cancer
carcinoma
Carcinoma
cell
Colorectal Neoplasms
colorectal tumor
evolution
gene expression
human
Humans
immune response
immune system
immunotherapy
Immunotherapy
pathology
transformation
tumor
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