Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells

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T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and bone marrow failure syndrome which responds to immunosuppressive therapies. We show single-cell TCR coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. E...

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Bibliographic Details
Main Authors: Alemu, L. (Author), Arnold, B. (Author), Barrett, J. (Author), Batchu, S. (Author), Diamond, C. (Author), Feng, X. (Author), Gao, S. (Author), Giudice, V. (Author), Ito, S. (Author), Kajigaya, S. (Author), Raffo, D.Q (Author), Wu, Z. (Author), Young, N.S (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
alemtuzumab
Alemtuzumab
cell clone
Clone Cells
genetics
human
Humans
large granular lymphocyte leukemia
Leukemia, Large Granular Lymphocytic
lymphocyte antigen receptor
Receptors, Antigen, T-Cell
sequence analysis
Sequence Analysis, RNA
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