STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming

STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming

The cohesin complex participates in the organization of 3D genome through generating and maintaining DNA loops. Stromal antigen 2 (STAG2), a core subunit of the cohesin complex, is frequently mutated in various cancers. However, the impact of STAG2 inactivation on 3D genome organization, especially...

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Main Authors: Boland, G.M (Author), Cai, L. (Author), Chen, J. (Author), Chu, Z. (Author), Feng, A. (Author), Flaherty, K.T (Author), Frederick, D.T (Author), Geng, S. (Author), Georgopoulos, K. (Author), Gu, L. (Author), Hu, Y. (Author), Huang, M. (Author), Li, M. (Author), Liu, D. (Author), Niu, Z. (Author), Piris, A. (Author), Qi, Y. (Author), Shen, C.-H (Author), Shi, Y. (Author), Specht, E. (Author), Sullivan, R.J (Author), Teng, D. (Author), Yoshida, T. (Author), Zhang, X. (Author), Zheng, B. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
antigen
cancer
DNA
gene expression
genome
protein
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