Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium

Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium

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Intestinal inflammation fuels the transmission of Salmonella Typhimurium (S.Tm). However, a substantial fitness cost is associated with virulence expression. Mutations inactivating transcriptional virulence regulators generate attenuated variants profiting from inflammation without enduring virulenc...

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Bibliographic Details
Main Authors: Bakkeren, E. (Author), Diard, M. (Author), Gül, E. (Author), Hardt, W.-D (Author), Huisman, J.S (Author), Rocker, A. (Author), Steiger, Y. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
allele
article
bacterial colonization
bacterial protein
Bacterial Proteins
bacterial virulence
bacterium
conjugative plasmid
emergence
fitness
gene expression regulation
Gene Expression Regulation, Bacterial
gene frequency
gene transfer
Gene Transfer, Horizontal
genetics
horizontal gene transfer
human
Humans
inflammation
Inflammation
metabolism
nonhuman
plasmid
regulator gene
Salmonella enterica serovar Typhimurium
Salmonella typhimurium
transcription factor
Transcription Factors
virulence
Virulence
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