Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

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In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete understanding of the microenvironment’s role in β-cell development and matu...

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Bibliographic Details
Main Authors: Borowiak, M. (Author), Chmielowiec, J. (Author), Sabek, O.M (Author), Sarrion-Perdigones, A. (Author), Scavuzzo, M.A (Author), Szlachcic, W.J (Author), Venken, K.J.T (Author), Wamble, K. (Author), Yang, D. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cell differentiation
Cell Differentiation
genetics
human
Humans
metabolism
pancreas
Pancreas
physiology
Wnt signaling
Wnt Signaling Pathway
Wnt5a protein
Wnt-5a Protein
WNT5A protein, human
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