Genetic analysis of over half a million people characterises C-reactive protein loci

Genetic analysis of over half a million people characterises C-reactive protein loci

Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Resea...

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Bibliographic Details
Main Authors: Alizadeh, B.Z (Author), Bodinier, B. (Author), Chadeau-Hyam, M. (Author), Chasman, D.I (Author), Dehghan, A. (Author), Elliott, P. (Author), Evangelou, E. (Author), Jarvelin, M.-R (Author), Karhunen, V. (Author), Koskeridis, F. (Author), Ligthart, S. (Author), Pazoki, R. (Author), Said, S. (Author), Sattar, N. (Author), Tzoulaki, I. (Author), Võsa, U. (Author), Welsh, P. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
blood
C reactive protein
C-Reactive Protein
gene expression
gene locus
genetic analysis
Genetic Loci
genetics
genome
genome-wide association study
Genome-Wide Association Study
human
Humans
inflammation
Inflammation
male
Male
Mendelian randomization analysis
Mendelian Randomization Analysis
metabolism
Phenomics
Polymorphism, Single Nucleotide
protein
single nucleotide polymorphism
United Kingdom
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