A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur. Here, we report the rational design of a fluorogenic peptide able to detect picomolar concentrations of active granzyme B as a biomarker of i...

Full description

Bibliographic Details
Main Authors: Akram, A.R (Author), Barth, N.D (Author), Bravo-Blas, A. (Author), Carragher, N.O (Author), Cheng, Z. (Author), Connor, R.A.O (Author), Dawson, J. (Author), de Vries, I.J (Author), Frame, M. (Author), Gordon, D. (Author), Juarez-Jimenez, J. (Author), Kitamura, T. (Author), Mendive-Tapia, L. (Author), Michel, J. (Author), Piet, B. (Author), Roberts, E.W (Author), Scott, J.I (Author), Serrels, A. (Author), Taggart, D. (Author), Thompson, E.J (Author), Vendrell, M. (Author), Verdoes, M. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
biopsy
Biopsy
granzyme
Granzymes
human
Humans
immunotherapy
Immunotherapy
Lung Neoplasms
lung tumor
Mice
mouse
peptide
Peptides
research
Research
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items