USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome pro...

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Bibliographic Details
Main Authors: Chen, D. (Author), Chen, H. (Author), Du, J. (Author), Guo, X. (Author), Lin, Z. (Author), Liu, J. (Author), Liu, X. (Author), Lu, C. (Author), Luo, H. (Author), Ma, C. (Author), Ning, Z. (Author), Otkur, W. (Author), Piao, H.-L (Author), Qi, H. (Author), Qin, W. (Author), Tan, G. (Author), Wang, A. (Author), Wang, W. (Author), Wang, X. (Author), Xia, T. (Author), Xu, G. (Author), Zhou, L. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
biological development
cell component
enzyme
enzyme activity
fatty acid
inhibition
stabilization
tumor
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