Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility...

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Bibliographic Details
Main Authors: Chen, L. (Author), Gao, D. (Author), Gao, S. (Author), Guo, S. (Author), Han, M. (Author), He, J. (Author), Jin, G. (Author), Jing, W. (Author), Li, Y. (Author), Liu, Z. (Author), Shi, X. (Author), Tang, S. (Author), Wang, H. (Author), Wang, Y. (Author), Xu, X. (Author), Yuan, Q. (Author), Zhang, X. (Author), Zhang, Y. (Author), Zheng, K. (Author), Zhu, Y. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cancer
cell component
drug
integrated approach
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