A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis mechanisms under specific cancer genetic contexts. KEAP1 (kelch-like ECH associated protein 1) is frequently mutated or inact...

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Bibliographic Details
Main Authors: Das, M. (Author), Gan, B. (Author), Horbath, A. (Author), Kondiparthi, L. (Author), Koppula, P. (Author), Lei, G. (Author), Li, W. (Author), Liu, X. (Author), Mao, C. (Author), Olszewski, K. (Author), Poyurovsky, M.V (Author), Shi, J. (Author), Yan, Y. (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cancer
cell
ferroptosis
Ferroptosis
genetics
human
Humans
KEAP1 protein, human
kelch like ECH associated protein 1
Kelch-Like ECH-Associated Protein 1
lipid
lipid peroxidation
Lipid Peroxidation
Lung Neoplasms
lung tumor
metabolism
NF-E2-Related Factor 2
protein
transcription factor Nrf2
tumor
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