A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis mechanisms under specific cancer genetic contexts. KEAP1 (kelch-like ECH associated protein 1) is frequently mutated or inact...

Full description

Bibliographic Details
Main Authors:	Das, M. (Author), Gan, B. (Author), Horbath, A. (Author), Kondiparthi, L. (Author), Koppula, P. (Author), Lei, G. (Author), Li, W. (Author), Liu, X. (Author), Mao, C. (Author), Olszewski, K. (Author), Poyurovsky, M.V (Author), Shi, J. (Author), Yan, Y. (Author), Zhang, Y. (Author)
Format:	Article
Language:	English
Published:	Nature Research 2022
Subjects:	cancer cell ferroptosis Ferroptosis genetics human Humans KEAP1 protein, human kelch like ECH associated protein 1 Kelch-Like ECH-Associated Protein 1 lipid lipid peroxidation Lipid Peroxidation Lung Neoplasms lung tumor metabolism NF-E2-Related Factor 2 protein transcription factor Nrf2 tumor
Online Access:	View Fulltext in Publisher

Similar Items

Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment
by: Wanwan Cheng, et al.
Published: (2021-09-01)

Keap1 Expression for Predicting the Chemoresistance and Prognosis of Advanced  Non-small Cell Lung Cancer
by: Baoshan CAO, et al.
Published: (2012-10-01)

Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking
by: Xiu E. Feng, et al.
Published: (2017-12-01)

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update
by: Christina Thanas, et al.
Published: (2020-11-01)

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System
by: Dionysios V. Chartoumpekis, et al.
Published: (2020-09-01)

Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer
by: Cedric O. Renaud, et al.
Published: (2019-08-01)

Epigenetic Scanning of <i>KEAP1 </i>CpG Sites Uncovers New Molecular-Driven Patterns in Lung Adeno and Squamous Cell Carcinomas
by: Federico Pio Fabrizio, et al.
Published: (2020-09-01)

DNA Protecting Activities of Nymphaea nouchali (Burm. f) Flower Extract Attenuate t-BHP-Induced Oxidative Stress Cell Death through Nrf2-Mediated Induction of Heme Oxygenase-1 Expression by Activating MAP-Kinases
by: Md Badrul Alam, et al.
Published: (2017-09-01)

Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer
by: Yoshiyuki Yamaguchi, et al.
Published: (2019-11-01)

Comparative Cytotoxicity Study of PM2.5 and TSP Collected from Urban Areas
by: Ilseob Shim, et al.
Published: (2021-07-01)

Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound
by: Katsuya Iuchi, et al.
Published: (2020-05-01)

Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer
by: Jiangang Zhao, et al.
Published: (2020-11-01)

Natural Nrf2 Modulators for Skin Protection
by: Yong Chool Boo
Published: (2020-09-01)

Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress
by: Takamitsu Unoki, et al.
Published: (2020-01-01)

Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells
by: Siao-Pei Guo, et al.
Published: (2021-09-01)

OGT-Mediated KEAP1 Glycosylation Accelerates NRF2 Degradation Leading to High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease
by: Tian-Hua Xu, et al.
Published: (2020-10-01)

Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
by: Chunjing Yang, et al.
Published: (2020-05-01)

Ferroptosis-Related Flavoproteins: Their Function and Stability
by: R. Martin Vabulas
Published: (2021-01-01)

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
by: Bradley A. Carlson, et al.
Published: (2016-10-01)

Novel mutations in the 3-box motif of the BACK domain of KLHL7 associated with nonsyndromic autosomal dominant retinitis pigmentosa
by: Jin Kyun Oh, et al.
Published: (2019-12-01)

Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets
by: Sabrina Taliani, et al.
Published: (2020-05-01)

Ferroptosis, a New Insight Into Acute Lung Injury
by: Xiaofang Yin, et al.
Published: (2021-08-01)

Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines
by: Margaretha A. Skowron, et al.
Published: (2017-08-01)

The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway
by: Juan Liu, et al.
Published: (2020-11-01)

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
by: Karthikeyan Subburayan, et al.
Published: (2020-11-01)

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals
by: Da-Young Lee, et al.
Published: (2021-05-01)

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
by: Boutaina Daher, et al.
Published: (2020-05-01)

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review
by: Pengxu Lei, et al.
Published: (2019-02-01)

Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg?
by: Xin Chen, et al.
Published: (2021-03-01)

Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease
by: Kai Chen, et al.
Published: (2021-08-01)

Ferroptosis and Its Role in Epilepsy
by: Yuxiang Cai, et al.
Published: (2021-07-01)

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway
by: Sufang Shui, et al.
Published: (2021-09-01)

Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice
by: Xiao-Yuan Mao, et al.
Published: (2019-07-01)

Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
by: Shi Dong, et al.
Published: (2021-09-01)

Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases
by: Xintong Wang, et al.
Published: (2021-09-01)

The Multifaceted Regulation of Mitochondria in Ferroptosis
by: Hao Wu, et al.
Published: (2021-03-01)

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis
by: Yuan Yuan, et al.
Published: (2021-06-01)

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes
by: Dan Li, et al.
Published: (2020-09-01)

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination
by: Andres Ramirez-Martinez, et al.
Published: (2017-08-01)

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
by: Sergei A. Novgorodov, et al.
Published: (2018-02-01)