Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by interactions between hundreds of risk variants. Epigenetic factors, such as histone posttranslational modifications (PTMs), have been shown to play critical roles in many neurodevelopmental processes, and when perturb...

Full description

Bibliographic Details
Main Authors: Bastle, R.M (Author), Bhanu, N.V (Author), Brennand, K.J (Author), Cetin, B. (Author), Chan, J.C (Author), Farrelly, L.A (Author), Flaherty, E. (Author), Garcia, B.A (Author), Gleason, K. (Author), Li, H. (Author), Maze, I. (Author), Ramakrishnan, A. (Author), Schrode, N. (Author), Shen, L. (Author), Tamminga, C.A (Author), Topol, A. (Author), Zheng, S. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
acetylation
Acetylation
BRD4 protein, human
cell cycle protein
Cell Cycle Proteins
chromatin
Chromatin
genetics
histone
Histones
human
Humans
induced pluripotent stem cell
Induced Pluripotent Stem Cells
metabolism
nerve cell
Neurons
nuclear protein
Nuclear Proteins
protein processing
Protein Processing, Post-Translational
schizophrenia
Schizophrenia
transcription factor
Transcription Factors
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items