Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice

Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice

Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones and DNA methylation. Similar processes in mammals can also affect phenotype through intergenerational or trans-generational mechanisms. Here...

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Main Authors: Bruno, L. (Author), Castillo-Fernandez, J. (Author), Dimond, A. (Author), Ferguson-Smith, A.C (Author), Fisher, A.G (Author), French, P.M.W (Author), Galvão, A.M (Author), John, R.M (Author), Kelsey, G. (Author), McGinty, J. (Author), McNamara, G. (Author), Merkenschlager, M. (Author), Millership, S.J (Author), Prodani, C. (Author), Sardini, A. (Author), To, W. (Author), Uren, A.G (Author), Van de Pette, M. (Author), Watkinson, W. (Author), Webster, Z. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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