Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is unknown. To elucidate the molecular basis of BMP:BMPRII interactions, we r...

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Bibliographic Details
Main Authors: Guo, J. (Author), Li, W. (Author), Li, X. (Author), Liu, B. (Author), Morrell, N.W (Author), Read, R.J (Author), Salmon, R.M (Author), ten Dijke, P. (Author), Thorikay, M. (Author), Tong, Z. (Author), Yu, M. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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