Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen aiming at identifying SARS-CoV-2 restriction factors. We identify DAXX, a...

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Main Authors: Aicher, S.-M (Author), Arhel, N. (Author), Baidaliuk, A. (Author), Bruel, T. (Author), Carlson-Stevermer, J. (Author), Chazal, M. (Author), Donati, F. (Author), Hardy, A. (Author), Holden, K. (Author), Jouvenet, N. (Author), Maarifi, G. (Author), Mac Kain, A. (Author), Munier, S. (Author), Nisole, S. (Author), OhAinle, M. (Author), Oki, J. (Author), Porrot, F. (Author), Roesch, F. (Author), Schwartz, O. (Author), Simon-Lorière, E. (Author), Tran, Q.D (Author), Vallet, T. (Author), van der Werf, S. (Author), Vignuzzi, M. (Author), Zimmer, G. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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