T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect of cholesterol efflux pathways mediated by ATP-binding cassette A1 and G1 (ABCA1/ABCG1) on T cell-dependent age-rela...

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Main Authors: Bazioti, V. (Author), Bianchi, F. (Author), Dabral, D. (Author), de Boer, R. (Author), de Bruin, A. (Author), Flohr-Svendsen, A. (Author), Groenen, A.G (Author), Guilbaud, E. (Author), Halmos, B. (Author), Havinga, R. (Author), Kloosterhuis, N.J (Author), Kohan, A.B (Author), Koster, M.H (Author), La Rose, A.M (Author), Langelaar-Makkinje, M. (Author), Maassen, S. (Author), Marmolejo-Garza, A. (Author), Pranger, A.T (Author), van de Sluis, B. (Author), van den Bogaart, G. (Author), Westerterp, M. (Author), Yvan-Charvet, L. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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