Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activation. Here, we report structures of human Kv1.3 alone, with a n...

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Bibliographic Details
Main Authors: Fernández-Mariño, A.I (Author), He, C. (Author), Huang, R. (Author), Khanra, N. (Author), Meyerson, J.R (Author), Paquette, A.J (Author), Rice, W.J (Author), Selvakumar, P. (Author), Smider, V.V (Author), Swartz, K.J (Author), Wang, B. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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