Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

CD1a is a monomorphic antigen-presenting molecule on dendritic cells that presents lipids to αβ T cells. Whether CD1a represents a ligand for other immune receptors remains unknown. Here we use CD1a tetramers to show that CD1a is a ligand for Vδ1+ γδ T cells. Functional studies suggest that two γδ T...

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Bibliographic Details
Main Authors: Cao, T.-P (Author), Gully, B.S (Author), Gunasinghe, S.D (Author), Le Nours, J. (Author), Moody, D.B (Author), Ocampo, T.A (Author), Reijneveld, J.F (Author), Rossjohn, J. (Author), Tin, S.Y (Author), Van Rhijn, I. (Author), von Borstel, A. (Author), Wegrecki, M. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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