Sex differences in heart mitochondria regulate diastolic dysfunction

Sex differences in heart mitochondria regulate diastolic dysfunction

Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias. As part of genetic studies of heart failure in mice, we observe that heart mitochondrial DNA levels and fun...

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Bibliographic Details
Main Authors: Cao, Y. (Author), Charugundla, S. (Author), Chella Krishnan, K. (Author), Kimball, T.H (Author), Lusis, A.J (Author), Moore, T.M (Author), Pan, C. (Author), Rau, C.D (Author), Reue, K. (Author), Rosa-Garrido, M. (Author), Seldin, M.M (Author), Vergnes, L. (Author), Vondriska, T.M (Author), Wang, J. (Author), Wang, Y. (Author), Wang, Y.-C (Author), Zhou, Z. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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