Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction

Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction

Biologically active vitamin B6-derivative pyridoxal 5′-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is achieved is still not well understood. Such compr...

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Bibliographic Details
Main Authors: Blakeley, M.P (Author), Devos, J.M (Author), Drago, V.N (Author), Forsyth, V.T (Author), Kovalevsky, A.Y (Author), Mueser, T.C (Author), Schall, C.A (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
Amino acids
Amino-acids
Cofactors
Crystal growth
Crystals
Enzyme catalysis
Enzymes
Metabolic pathways
Microgravity
Microgravity processing
Mosaicity
Neutron diffraction
Neutron diffraction data
Neutrons
Protein crystal growth
Pyridoxal 5′-phosphate
Space stations
Tryptophan Synthase
Vitamin B-6
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